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. 1990 Sep;16(2):97-102.
doi: 10.1007/BF01809293.

Estimation of epidermal growth factor receptor in 177 breast cancers: correlation with prognostic factors

M Bolla  1 , M Chedin, C Souvignet, J Marron, C Arnould, E Chambaz
Affiliations

Estimation of epidermal growth factor receptor in 177 breast cancers: correlation with prognostic factors

M Bolla et al. Breast Cancer Res Treat. 1990 Sep.

Abstract

Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of 125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation.

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