Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2011 Aug;61 Suppl 3(Suppl 3):60-6.
doi: 10.1111/j.1875-595X.2011.00051.x.

A randomised clinical trial to assess control of oral malodour by a novel dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride

David Payne  1 , Jenny J Gordon, Stephanie Nisbet, Ritu Karwal, Mary Lynn Bosma
Affiliations
Randomized Controlled Trial

A randomised clinical trial to assess control of oral malodour by a novel dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride

David Payne et al. Int Dent J. 2011 Aug.

Abstract

Objectives: To assess the ability of a 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice to control oral malodour compared to a sodium fluoride control dentifrice.

Design: Following baseline measurement of oral volatile sulfur compounds (VSCs), the subjects brushed twice daily for 1 week with either the test or control dentifrice. The VSC concentration in breath samples was monitored up to 12 hours post-treatment, by gas chromatography (GC).

Results: 75 subjects were included in the efficacy analysis. Relative to the sodium fluoride control dentifrice group the o-cymen-5-ol/ zinc chloride/ sodium fluoride dentifrice exhibited statistically significant reductions (P<0.0001) in hydrogen sulfide, methyl mercaptan and total measured VSCs immediately and after 1, 2, 3 and 12 (overnight) hours post-treatment.

Conclusion: The results of the present clinical study demonstrated that the use of the 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice over a one week period provided a statistically significant benefit in controlling oral malodour for up to 12 hours post-treatment compared to a sodium fluoride control dentifrice.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Change from baseline of hydrogen sulfide levels (log scale (base: 10)) by treatment (adjusted mean ± standard error (SE))– ITT population. Error bars represent between-subject standard error. Experimental Dentifrice (Test) - 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice. NaF dentifrice (Reference) - Sodium fluoride dentifrice. The first point is the 12 hour (overnight) time-point, the second point is the immediately after treatment (+5 min).
Figure 2.
Figure 2.
Change from baseline of methyl mercaptan levels (log scale (base: 10)) by treatment (adjusted mean ± SE)– ITT population. Error bars represent between-subject standard error. Experimental Dentifrice (Test) - 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/sodium fluoride dentifrice. NaF dentifrice (Reference) - Sodium fluoride dentifrice. The first point is the 12 hour (overnight) time-point, the second point is the immediately after treatment (+5 min).
Figure 3.
Figure 3.
Change from baseline of total VSC (hydrogen sulfide + methyl mercaptan) levels (log scale (base: 10)) by treatment (adjusted mean ± SE)– ITT population. Error bars represent between-subject standard error. Experimental Dentifrice (Test) - 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice. NaF dentifrice (Reference) - Sodium fluoride dentifrice. The first point is the 12 hour (overnight) time-point, the second point is the immediately after treatment (+5 min).
See this image and copyright information in PMC

References

    1. Hughes FJ, McNab R. Oral malodour-a review. Arch Oral Biol. 2008;53(Suppl 1):S1–S7. - PubMed
    1. Porter SR, Scully C. Oral malodour (halitosis) Br Med J. 2006;333:632–635. - PMC - PubMed
    1. Settineri S, Mento C, Gugliotta SC, Saitta A, Terranova A, Trimarchi G, et al. Self-reported halitosis and emotional state: impact on oral conditions and treatments. Health Qual Life Outcomes. 2010;8:34. - PMC - PubMed
    1. Murata T, Yamaga T, Iida T, et al. Classification and examination of halitosis. Int Dent J. 2002;52(Suppl 3):181–186. - PubMed
    1. Rosenberg M. Diagnosis and treatment of bad breath. Cosmetics & Toiletries Magazine. 1996;111:85–90.

Publication types