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Multicenter Study
. 2011 Aug;13(8):544-50.
doi: 10.1111/j.1477-2574.2011.00322.x. Epub 2011 Jun 24.

Experience using liver transplantation for the treatment of severe bile duct injuries over 20 years in Argentina: results from a National Survey

Victoria Ardiles  1 , Lucas McCormack, Emilio Quiñonez, Nicolás Goldaracena, Juan Mattera, Juan Pekolj, Miguel Ciardullo, Eduardo de Santibañes
Affiliations
Multicenter Study

Experience using liver transplantation for the treatment of severe bile duct injuries over 20 years in Argentina: results from a National Survey

Victoria Ardiles et al. HPB (Oxford). 2011 Aug.

Abstract

Background: Bile duct injury (BDI) is a severe complication that may arise during the surgical treatment of benign disease and a few patients will develop end-stage liver disease (ESLD) requiring a liver transplant (LT).

Objective: Analyse the experience using LT as a definitive treatment of BDI in Argentina.

Patients and methods: A national survey regarding the experience of LT for BDI.

Results: Sixteen out 18 centres reported a total of 19 patients. The percentage of LT for BDI from the total number of LT per period was: 1990-94 = 3.1%, 1995-99 = 1.6%, 2000-04 = 0.7% and 2005-09 = 0.2% (P < 0.001). The mean age was 45.7 ± 10.3 years (range 26-62) and 10 patients were female. The BDI occurred during cholecystectomy in 16 and 7 had vascular injuries. One patient presented with acute liver failure and the others with chronic ESLD. The median time between BDI and LT was 71 months (range 0.2-157). The mean follow-up was 8.3 years (10 months to 16.4 years). Survival at 1, 3, 5 and 10 years was 73%, 68%, 68% and 45%, respectively.

Conclusions: The use of LT for the treatment of BDI declined over the review period. LT plays a role in selected cases in patients with acute liver failure and ESLD.

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Figures

Figure 1
Figure 1
Percentage of liver transplant (LT) by bile duct injury (BDI) of total LT per period
Figure 2
Figure 2
Overall post-transplant survival
See this image and copyright information in PMC

References

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