[The value of lysinopril in cardiac insufficiency]

Abstract

Owing to its original pharmacokinetic profile, lisinopril can be taken once a day, independently of meals, providing a 24-hour inhibition of the angiotensin-converting enzyme. Lisinopril is a potent angiotensin-converting enzyme inhibitor. Administered in doses of 2.5 to 20 mg per day, it improves the functional and haemodynamic state of patients whose congestive heart failure is refractory to the digitalis-diuretic treatment. The drug is well tolerated, and no severe side-effects have been reported. Lisinopril seems to be at least as effective as captopril in congestive heart failure, and it has over the latter the advantage of a once a day dosage therapy.