Utilization and yield of chest computed tomographic angiography associated with low positive D-dimer levels

Abstract

Background: It is unclear to what degree broadly applied D-dimer testing combined with a low threshold for imaging with even minimally positive results may be contributing to the utilization of chest computed tomographic angiography (CTA).

Study objectives: To determine what proportion of chest CTAs for suspected pulmonary embolism (PE) were performed in the setting of minimally elevated D-dimer levels, and to determine the prevalence of PE in those patients when stratified by clinical risk.

Methods: Retrospective chart review of all patients who had chest CTA for the evaluation of suspected PE during the years 2002-2006 in a suburban community teaching hospital emergency department.

Results: There were 1136 eligible patient visits, of which 353 (31.1%) were found to have D-dimer levels in the low positive range (0.5-0.99 μg/mL). Of these 353 patients, 9 (2.6%; 95% confidence interval [CI] 0.9-4.2%) were diagnosed with PE. There were also 109 patients (9.6%) who had normal D-dimer levels (<0.5 μg/mL). Two of these 109 (1.8%; 95% CI 0-4.2%) were diagnosed with PE. When stratified by the Pulmonary Embolism Rule-out Criteria, 99 of 353 patients with low positive D-dimer levels (28.0%; 95% CI 23.4-32.7%), and 14 of 109 with normal D-dimer levels (12.8%; 95% CI 6.6-19.1%) were classified as low risk, none of whom had PE.

Conclusions: Nearly one-third of all chest CTAs were done for patients with minimally elevated D-dimer levels, and another 9.6% for patients with normal D-dimer levels with very low yield. Further research to define clinical criteria identifying patients with minimal risk of PE despite low positive D-dimer levels represents an opportunity to improve both patient safety and utilization efficiency of chest CTA.