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Review
. 2011 Oct 12;111(10):5922-43.
doi: 10.1021/cr100396c. Epub 2011 Jul 18.

Resolvins and protectins in inflammation resolution

Charles N Serhan  1 , Nicos A Petasis
Affiliations
Review

Resolvins and protectins in inflammation resolution

Charles N Serhan et al. Chem Rev. .
No abstract available

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Figures

Figure 1
Figure 1
From initiation of acute inflammation to resolution: The inflammatory response to microbial infection and tissue injury, and the role of selected cell types and specialized pro-resolving lipid mediators.
Figure 2
Figure 2
Biosynthetic cascades and actions of selected lipid mediators derived from arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Figure 3
Figure 3
Inflammatory response and resolution time course: Roles of pro-resolving lipid mediators.
Figure 4
Figure 4
E-series resolvin biosynthesis and metabolic inactivation.
Figure 5
Figure 5
Design and synthesis of RvE1, RvE1 isomers and metabolically stable RvE1 analogs.
Figure 6
Figure 6
Metabolites of RvE1.
Figure 7
Figure 7
Pathways and enzymes in the biosynthesis of D-series resolvins.
Figure 8
Figure 8
Pathways and enzymes involved in the biosynthesis of aspirin-triggered D-series resolvins.
Figure 9
Figure 9
Synthetic scheme for RvD1 and RvD2.
Figure 10
Figure 10
Metabolites of RvD1.
Figure 11
Figure 11
Pathways and enzymes involved in the biosynthesis of protectin (PD1/NPD1) and 10S,17S-diHDHA.
Figure 12
Figure 12
Synthetic scheme for PD1/NPD1 synthesis and related isomers.
Figure 13
Figure 13
Potent stereoselective actions of PD1/NPD1 stereoisomers in murine peritonitis.
See this image and copyright information in PMC

References

    1. Cotran RS, Kumar V, Collins T, editors. Robbins Pathologic Basis of Disease. 6. W.B. Saunders Co; Philadelphia: 1999.
    1. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. J Exp Med. 2000;192:1197. - PMC - PubMed
    1. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Nat Immunol. 2001;2:612. - PubMed
    1. Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac R-L. J Exp Med. 2002;196:1025. - PMC - PubMed
    1. Serhan CN. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2005;73:141. - PubMed

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