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Review
. 2011 Jul 18:6:92.
doi: 10.1186/1749-8090-6-92.

A review of bronchiolitis obliterans syndrome and therapeutic strategies

Don Hayes Jr  1
Affiliations
Review

A review of bronchiolitis obliterans syndrome and therapeutic strategies

Don Hayes Jr. J Cardiothorac Surg. .

Abstract

Lung transplantation is an important treatment option for patients with advanced lung disease. Survival rates for lung transplant recipients have improved; however, the major obstacle limiting better survival is bronchiolitis obliterans syndrome (BOS). In the last decade, survival after lung retransplantation has improved for transplant recipients with BOS. This manuscript reviews BOS along with the current therapeutic strategies, including recent outcomes for lung retransplantation.

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Figures

Figure 1
Figure 1
Representative histopathology of obliterative bronchiolitis with inflammation and fibrosis of the airway with sparing of the surrounding alveoli (Hematoxylin and Eosin stain).
Figure 2
Figure 2
High resolution CT scan of the chest demonstrating bilateral bronchiectasis (right more severe than left) in a patient who underwent right single lung transplantation in 1992 for alpha-1-antitrypsin deficiency and left single lung transplantation in 2003 for bronchiolitis obliterans syndrome.
See this image and copyright information in PMC

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