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Case Reports
. 2011 Apr 4;3(2):e20.
doi: 10.4081/rt.2011.e20.

Intracerebral metaplastic meningioma with prominent ossification and extensive calcification

Jingxiang Huang  1 , Fredrik Petersson
Affiliations
Case Reports

Intracerebral metaplastic meningioma with prominent ossification and extensive calcification

Jingxiang Huang et al. Rare Tumors. .

Abstract

We present a patient (male 26 years) with a short history of recurrent seizures induced by a largely intracerebrally located frontal lobe meningioma. The tumor displayed a heretofore unpublished combination of extensive metaplastic bone formation and prominent non-psammomatous calcifications with focal chicken-wire pattern.

Keywords: brain; calcification.; meningioma; metaplastic; ossification.

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Figures

Figure 1
Figure 1
A right frontal lobe tumor. Magnetic resonance imaging scan of the brain was performed and revealed a 4.0− cm calcified tumor associated with edema of the adjacent brain parenchyma.
Figure 2
Figure 2
A heterogeneous tumor with areas of calcification and bone formation. (A) Tumor seen at low power showing cellular areas with areas of calcification and ossification. (B) The cellular areas are composed of plump, elongated cells with meningothelial features. (C) Prominent lymphoplasmacytic infiltrate is present within the cellular areas. (D) The highly vascularized tumour also contain dysplastic blood vessels. (E) The areas of calcification show crystalline deposits of calcium merge seamlessly with woven bone. No osteoblastic rimming is seen. (F) An interlacing chicken-wire-like calcification is seen in several areas.
Figure 3
Figure 3
Bone formation within the tumour. Bony trabeculae with no osteoblastic rimming is seen within the tumour.
Figure 4
Figure 4
The tumor expresses epithelial membrane antigen and progesterone receptor. Sections of the tumor were stained with anti-EMA and anti-progesterone receptor primary antibodies and couterstained with hematoxylin. (A) Diffuse expression of cytoplasmic EMA is seen. (B) Scattered cells show nuclear expression of progesterone receptor.
See this image and copyright information in PMC

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