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. 1979 Jan 15;35(1):132-3.
doi: 10.1007/BF01917922.

Influence of alpha-MSH and ACTH on cortical bone remodelling in hypophysectomized rats

A Stenström, L I Hansson, K G Thorngren

Influence of alpha-MSH and ACTH on cortical bone remodelling in hypophysectomized rats

A Stenström et al. Experientia. .

Abstract

Hypophysectomy increases both periosteal resorption and endosteal apposition along the femur diaphysis in rat. Administration of alpha-MSH decreased the periosteal resorption but had no effect on the endosteal apposition. ACTH had only minor effects on the endosteum. Thus, alpha-MSH and ACTH, in the doses used, have different effects on cortical bone in rat. The effect of alpha-MSH on cortical bone could be an effect of the hormone alone or by its stimulation of other factors.

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