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. 2011 Sep;31(5):390-3.
doi: 10.1111/j.1475-097X.2011.01030.x. Epub 2011 Jun 12.

Endothelium-independent dilation in children and adolescents

Kara L Marlatt  1 , Meghan C McCue, Aaron S Kelly, Andrea M Metzig, Julia Steinberger, Donald R Dengel
Affiliations

Endothelium-independent dilation in children and adolescents

Kara L Marlatt et al. Clin Physiol Funct Imaging. 2011 Sep.

Abstract

Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5 min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0·3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 years) via ultrasound imaging of the brachial artery following NTG administration. Time to peak EID was 268 s following NTG administration, with no significant (P = 0·6) difference between males and females. There was a significant (P<0·001) difference between EID post-NTG at the 3 versus 4 min, 4 versus 5-min, and 3 versus 5 min time points. Peak EID (males: 24·8 ± 0·5 versus females: 25·3 ± 0·6%, P = 0·6) was not significantly different after accounting for baseline diameter. Peak response to NTG administration occurs between 4 and 5 min. The results demonstrate the importance of measuring EID up to 5-min post-NTG administration in youth.

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Figures

Figure 1
Figure 1
Average time course of endothelial-independent dilation (EID) for the entire study population (N=198) (●), as well as separated between males (■) and females (▲) from 0 to 5 min. Significant (p<0.05) differences were reported at 3 vs. 4 min (*), 3 vs. 5 min (**), and 4 vs. 5 min (‡) within the entire study population when adjusted for differences in baseline diameter.
See this image and copyright information in PMC

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