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. 2011 Dec 17;378(9809):e23-5.
doi: 10.1016/S0140-6736(11)61136-7. Epub 2011 Jul 21.

Antiretroviral prophylaxis: a defining moment in HIV control

Salim S Abdool Karim  1 , Quarraisha Abdool Karim
Affiliations

Antiretroviral prophylaxis: a defining moment in HIV control

Salim S Abdool Karim et al. Lancet. .
No abstract available

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Conflict of interest statement

Conflict of interest statement:

We were the co-Principal Investigators of the CAPRISA 004 trial of tenofovir gel. QAK is co-Principal Investigator of the HIV Prevention Trials Network, which is undertaking HPTN 052 trial of treatment for prevention. SSAK is an executive committee member of the Microbicide Trials Network, which is undertaking VOICE trial of oral and topical PrEP.

Figures

Figure 1
Figure 1
HIV prevention technologies shown to be effective in reducing HIV incidence in randomised controlled trials1-11 PrEP = Pre-Exposure Prophylaxis. *Meta analysis of circumcision trials
See this image and copyright information in PMC

References

    1. Partners PrEP study press release. Pivotal study finds that HIV medications are highly effective as prophyalxis against HIV infection in men and women in Africa. 2011. [accessed July 13, 2011]. http://depts.washington.edu/uwicrc/research/studies/files/PrEP_PressRele....
    1. Centers for Diseases Control and Prevention. [accessed July 13, 2011];CDC trial and another major study find PrEP can reduce risk of HIV infection among heterosexuals. 2011 July 13; http://www.cdc.gov/nchhstp/newsroom/PrEPHeterosexuals.html.
    1. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–1174. - PMC - PubMed
    1. Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N EnglJMed. 2010;363:2587–2599. - PMC - PubMed
    1. HPTN 052 press release. [accessed May 12, 2011];Initiation of antiretroviral treatment protects uninfected sexual partners from HIV infection (HPTN Study 052) 2011 http://www.hptn.org/web%20documents/PressReleases/HPTN052PressReleaseFIN....