Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Mrazek reported developing intellectual property that has been licensed by AssureRX Health and subsequently incorporated into physician decision support software and receiving research funding from AssureRX Health to create and maintain a bibliographic system designed to regularly monitor the scientific literature. Dr Mrazek also reported receiving royalties from the sale of a book on pharmacogenomics, and he reported that his institution has received medication from Forest Laboratories for an NIH-funded pharmacogenomic probe study. Dr Lerman reported serving as a consultant to Pfizer Inc on pharmacogenetic testing for smoking cessation treatment and receiving research funding from and consulting for AstraZeneca, Targacept, Pfizer, and GlaxoSmithKline, for work unrelated to this Commentary. Dr Lerman also reported receiving compensation for expert testimony.