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Clinical Trial
. 2011 Jul;4(4):467-76.
doi: 10.1161/CIRCOUTCOMES.110.960468.

Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH): design and rationale of a prospective multicenter registry

Suzanne V Arnold  1 , Paul S Chan, Philip G Jones, Carole Decker, Donna M Buchanan, Harlan M Krumholz, P Michael Ho, John A Spertus; Cardiovascular Outcomes Research Consortium
Affiliations
Clinical Trial

Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH): design and rationale of a prospective multicenter registry

Suzanne V Arnold et al. Circ Cardiovasc Qual Outcomes. 2011 Jul.

Abstract

Background: Black patients with myocardial infarction (MI) have worse outcomes than white patients, including higher mortality rates, more angina, and worse quality of life. The Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) study was designed to examine whether racial differences in socioeconomic, clinical, genetic, metabolic, biomarker, or treatment characteristics mediate observed disparities in outcomes.

Methods and results: Between April 11, 2005, and December 31, 2008, 31 567 patients with MI were prospectively screened; 6152 had an eligible MI, and 4340 (71%) were enrolled from 24 US centers. Consenting patients had detailed chart abstractions of their medical history and processes of inpatient care, supplemented with a detailed baseline interview. Detailed genetic and metabolic data were obtained at hospital discharge in 2979 (69%) and 3013 patients (69%), respectively. In a subset of patients, blood and urine samples were obtained at 1 month (obtained in 27% of survivors) and blood samples at 6 months (obtained in 19% of survivors). Centralized follow-up interviews sought to quantify patients' postdischarge care and outcomes, with a focus on their health status (symptoms, function, and quality of life). At 1, 6, and 12 months, 23%, 27%, and 24%, respectively, were lost to follow-up. Vital status was available for 99% of patients at 12 months.

Conclusions: TRIUMPH is a novel MI registry with detailed information on patients' sociodemographic, clinical, treatment, health status, metabolic, and genetic characteristics. The wealth of patient data collected in TRIUMPH will provide unique opportunities to examine factors that may mediate racial differences in mortality and health status after MI and the complex interactions between genetic and environmental determinants of post-MI outcomes.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr. Spertus owns the copyright to the Seattle Angina Questionnaire.

Figures

Figure 1
Figure 1
Potential mediators of clinical outcomes: overview of TRIUMPH data collection. AMI indicates acute myocardial infraction; CAD, coronary artery disease.
Figure 2
Figure 2
Detailed overview of potential mediators of post-MI outcomes. NSTEMI indicates non–st-elevation–MI; EF, ejection fraction; QOL, quality of life; SAQ, Seattle Angina Questionnaire; PCI, percutaneous coronary intervention; MDM, medical decision making; and CABG, coronary artery bypass graft.
Figure 3
Figure 3
Participating sites in the TRIUMPH registry.
Figure 4
Figure 4
Summary of follow-up on the patients enrolled in TRIUMPH.
See this image and copyright information in PMC

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