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Comment
. 2011 Jul 20;30(14):2757-8.
doi: 10.1038/emboj.2011.223.

Policing Parkin with a UblD

Fen Liu  1 , Kylie J Walters
Affiliations
Comment

Policing Parkin with a UblD

Fen Liu et al. EMBO J. .

Abstract

EMBO J 30 14, 2853–2867 (2011); published online June 21 2011

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Model of Parkin regulation by autoinhibition. Parkin is newly classified as RING/HECT-hybrid E3 ligase, with cysteine C431 proposed to form a thioester ubiquitin intermediate en route to substrate ubiquitination. The N-terminal ubiquitin-binding domain (UblD) binds to a C-terminal UblD-binding (PUB) site to block interaction with ubiquitin, restricting E2∼ubiquitin thioester discharge and Parkin autoubiquitination. This autoinhibition is lost in pathogenic parkin protein products with UblD mutations.
See this image and copyright information in PMC

Comment on

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