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Multicenter Study
. 2011 Aug 23;105(5):709-22.
doi: 10.1038/bjc.2011.254. Epub 2011 Jul 19.

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Endogenous Hormones and Breast Cancer Collaborative Group  1 ; T J Key, P N Appleby, G K Reeves, A W Roddam, K J Helzlsouer, A J Alberg, D E Rollison, J F Dorgan, L A Brinton, K Overvad, R Kaaks, A Trichopoulou, F Clavel-Chapelon, S Panico, E J Duell, P H M Peeters, S Rinaldi, I S Fentiman, M Dowsett, J Manjer, P Lenner, G Hallmans, L Baglietto, D R English, G G Giles, J L Hopper, G Severi, H A Morris, S E Hankinson, S S Tworoger, K Koenig, A Zeleniuch-Jacquotte, A A Arslan, P Toniolo, R E Shore, V Krogh, A Micheli, F Berrino, E Barrett-Connor, G A Laughlin, M Kabuto, S Akiba, R G Stevens, K Neriishi, C E Land, J A Cauley, Li Yung Lui, Steven R Cummings, M J Gunter, T E Rohan, H D Strickler
Collaborators, Affiliations
Multicenter Study

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Endogenous Hormones and Breast Cancer Collaborative Group et al. Br J Cancer. .

Abstract

Background: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood.

Methods: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies.

Results: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer.

Conclusion: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Geometric mean concentration of selected hormones in postmenopausal women by categories of age at blood collection, adjusted for study, type of menopause and BMI.
Figure 2
Figure 2
Geometric mean concentration of selected hormones in postmenopausal women by categories of type of menopause, adjusted for study, age at blood collection and BMI.
Figure 3
Figure 3
Geometric mean concentration of selected hormones in postmenopausal women by categories of BMI, adjusted for study, age at blood collection and type of menopause.
Figure 4
Figure 4
Geometric mean concentration of selected hormones in postmenopausal women by categories of smoking, adjusted for study, age at blood collection, type of menopause and BMI.
Figure 5
Figure 5
Geometric mean concentration of selected hormones in postmenopausal women by categories of usual alcohol consumption, adjusted for study, age at blood collection, type of menopause and BMI.
See this image and copyright information in PMC

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