Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar;14(2):111-6.

The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran

Nahid Reisi  1 , Afshin Azhir, Mahin Hashemipour, Pouran Raeissi, Abasgholi Amini, Alireza Moafi
Affiliations

The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran

Nahid Reisi et al. J Res Med Sci. 2009 Mar.

Abstract

Background: To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran.

Methods: During a 4-year period (2003 to 2007), 55 children (33 male and 22 female) diagnosed with ALL at Unit of Hematology/ Oncology, Department of Pediatrics, Isfahan University of Medical Science, were enrolled in this cross-sectional study. Metabolic syndrome was defined using the modified version of Adult Treatment Panel (ATP III) crite-ria. Insulin resistance was defined based on the homeostasis model assessment index (HOMA-IR).

Results: The mean age of participates was 10.4 years (range 6-19 years) and the mean interval since completion of chemotherapy was 35 months. Twenty percent (11/55) of survivors (10 male, 1 female) met criteria for diagnosis of metabolic syndrome. Obesity was observed in one forth of patients and nearly 3/4 of obese patients had metabolic syndrome. High serum insulin levels were found in 16% of participants and in 63% of obese survivors. The mean insulin levels in survivors with metabolic syndrome was three-times more than those without (28.3 mu/l vs. 9.57 mu/l, p = 0.004). Insulin resistance was detected in 72.7% of survivors with metabolic syndrome and it was positively correlated with serum triglycerides (0.543, p ≤ 0.001), systolic and diastolic BP (0.348, p = 0.01 and 0.368, p = 006 respectively), insulin levels (0.914, p < 0.001) and blood sugar (0.398, p = 003).

Conclusions: The prevalence of metabolic syndrome in survivors of childhood leukemia in Iran is higher than developed countries. Nearly all of the obese patients had metabolic syndrome. Weight control and regular physical exercise are recommended to the survivors.

Keywords: Acute lymphoblastic leukemia; children; metabolic syndrome; obesity.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interests

The authors have no conflicts of interest.

References

    1. Kadan-Lottick NS. Cancer and Benign tumor. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Saunders: Nelson textbook of pediatrics; 2007. pp. 2097–100.
    1. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, et al. National Cancer Institute; 2005. SEER cancer statistics review, 1975-2002.
    1. Silverman LB, Gelber RD, Dalton VK, Asselin BL, Barr RD, Clavell LA, et al. Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01. Blood. 2001;97(5):1211–8. - PubMed
    1. Davies HA. Late problems faced by childhood cancer survivors. Br J Hosp Med. 1993;50(2-3):137–40. - PubMed
    1. Gleeson HK, Shalet SM. Endocrine complications of neoplastic diseases in children and adolescents. Curr Opin Pediatr. 2001;13(4):346–51. - PubMed

LinkOut - more resources