Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:426813.
doi: 10.1155/2011/426813. Epub 2011 Jul 2.

Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine

Joseph V Pergolizzi  1 , Robert Raffa, Robert Taylor
Affiliations

Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine

Joseph V Pergolizzi et al. J Drug Deliv. 2011.

Abstract

Postoperative nausea and vomiting (PONV) is a relatively common occurrence (20-30%) that delays discharge and, if persistent, can lead to serious complications. The incidence of PONV is a function of patient characteristics, the type and duration of surgery, the type of anesthesia, and the choice of pre-, intra-, and postoperative pharmacotherapy. There are no completely effective antiemetic agents for this condition, but recommendations for treatment strategies are separately available for pediatric and adult patients. Left unclear is whether adolescents should be guided by the pediatric or the adult recommendations. We review the developmental physiology of the relevant physiological factors (absorption, distribution, metabolism, and elimination). We also review the clinical evidence regarding the safety and efficacy of a fixed-dose combination of ondansetron (4 mg, i.v.) and transdermal scopolamine (1.5 mg).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Transdermal scopolamine patch is affixed to skin, where it delivers a priming dose and then a slow release of scopolamine through a special rate-controlling membrane.
See this image and copyright information in PMC

References

    1. Philip BK. Etiologies of postoperative nausea and vomiting. Pharmacology & Therapeutics. 1997;229(supplement 7):18s–25s.
    1. Inpatient Surgery. CDC, 2009, http://www.cdc.gov/nchs/fastats/insurg.htm.
    1. Carroll NV, Miederhoff P, Cox FM, Hirsch JD. Postoperative nausea and vomiting after discharge from outpatient surgery centers. Anesthesia and Analgesia. 1995;80(5):903–909. - PubMed
    1. Carroll NV, Miederhoff PA, Cox FM, Hirsch JD. Costs incurred by outpatient surgical centers in managing postoperative nausea and vomiting. Journal of Clinical Anesthesia. 1994;6(5):364–369. - PubMed
    1. Purkis IE. Factors that influence postoperative vomiting. Canadian Anaesthetists’ Society Journal. 1964;11(4):335–353. - PubMed

LinkOut - more resources