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. 2011 Sep 14;47(34):9687-9.
doi: 10.1039/c1cc13571f. Epub 2011 Jul 19.

Development of encoded particle-polymer arrays for the accelerated screening of antifouling layers

Darby Kozak  1 , Prakash Kithva, Jacinda Bax, Peter P T Surawski, Michael J Monteiro, Matt Trau
Affiliations

Development of encoded particle-polymer arrays for the accelerated screening of antifouling layers

Darby Kozak et al. Chem Commun (Camb). .

Abstract

A multiplexed screening methodology for the rapid development of antifouling polymer surfaces is presented. An array of protein resistant polymer layers with high grafting (>100 mg m(-2)) were polymerized on optically encoded particles. Multiplexed analysis showed a 97% reduction in nonspecific protein adsorption for all polymer layers created.

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Figures

Fig. 1
Fig. 1
RAFT modification and on-particle polymer synthesis.
Fig. 2
Fig. 2
Fluorescent image and corresponding flow cytometric optical 2D micrograph of 41 optically encoded particle populations.
Fig. 3
Fig. 3
Flow cytometric readout of individual encoded particles before (black dots) and after (red dots) incubation with fluorescent protein. The middle population of the polymer library with greatest difference between black and red dots corresponds to MPMS-EMP particles without grafted polymer.
See this image and copyright information in PMC

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