doi: 10.1016/0888-7543(90)90253-q.
Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28
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- PMID: 2177445
- DOI: 10.1016/0888-7543(90)90253-q
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Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28
Genomics.
1990 Dec.
Abstract
We have isolated and characterized 55 EagI-containing genomic DNA clones from the distal long arm of the human X chromosome. The presence of additional sites for rare-cutter restriction enzymes and the demethylation of the corresponding genomic DNA demonstrate that at least 30 clones correspond to CpG islands of the Xq24-Xqter region. All clones were regionally mapped with a hybrid panel. The majority are in Xq28 and Xq24 (18 and 14 clones, respectively), 15 are in the Xq26-Xq27 interval, and none is in Xq25. This analysis demonstrates a nonuniform distribution of CpG islands that may reflect the distribution of coding regions in this part of the genome.
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