Multigenic control of virus virulence in intertypic recombinants of herpes simplex virus
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- PMID: 2177726
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Multigenic control of virus virulence in intertypic recombinants of herpes simplex virus
Indian J Exp Biol.
1990 Oct.
Abstract
The virulence of herpes simplex virus (HSV) type 1 x type 2 intertypic recombinants was determined following infection of corneas of outbred New Zealand White rabbits. None of the four recombinants was as virulent for rabbits as type 1 parent. All the four recombinants having an insert of type 2 virus genome between 0.35 and 0.576 map units (m.u.) and/or 0.82 and 1.00 m.u. exhibited intermediate virulence between their type 1 and type 2 parents. The results indicate that intertypic recombinants are moderated in their virulence independent of their parental virulence and therefore there exists a multigenic control of HSV virulence.
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