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. 1990 Oct;28(10):960-3.

Multigenic control of virus virulence in intertypic recombinants of herpes simplex virus

S K Batra  1 , S M Brown
Affiliations
  • PMID: 2177726

Multigenic control of virus virulence in intertypic recombinants of herpes simplex virus

S K Batra et al. Indian J Exp Biol. 1990 Oct.

Abstract

The virulence of herpes simplex virus (HSV) type 1 x type 2 intertypic recombinants was determined following infection of corneas of outbred New Zealand White rabbits. None of the four recombinants was as virulent for rabbits as type 1 parent. All the four recombinants having an insert of type 2 virus genome between 0.35 and 0.576 map units (m.u.) and/or 0.82 and 1.00 m.u. exhibited intermediate virulence between their type 1 and type 2 parents. The results indicate that intertypic recombinants are moderated in their virulence independent of their parental virulence and therefore there exists a multigenic control of HSV virulence.

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