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. 2011;31(6):443-50.
doi: 10.1159/000329543. Epub 2011 Jul 20.

Instrumental activities of daily living impairment is associated with increased amyloid burden

Gad A Marshall  1 , Lauren E Olson, Meghan T Frey, Jacqueline Maye, J Alex Becker, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
Affiliations

Instrumental activities of daily living impairment is associated with increased amyloid burden

Gad A Marshall et al. Dement Geriatr Cogn Disord. 2011.

Abstract

Background/aims: Instrumental activities of daily living (IADL) impairment in Alzheimer's disease has been associated with global amyloid deposition in postmortem studies. We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention.

Methods: Fifty-five subjects (19 normal older controls, NC, and 36 with mild cognitive impairment, MCI) underwent clinical assessments and dynamic PiB positron emission tomography imaging.

Results: A linear multiple regression model showed that greater IADL impairment was associated with greater global PiB retention in all subjects (R(2) = 0.40; unstandardized partial regression coefficient, β = 5.8; p = 0.0002) and in MCI subjects only (R(2) = 0.28; β = 6.1; p = 0.003), but not in NC subjects only.

Conclusion: These results suggest that daily functional impairment is related to greater amyloid burden in MCI.

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Figures

Fig. 1
Fig. 1
PiB distribution volume ratio (DVR) images from two transaxial levels representing NC, MCI, and AD subjects. These images exemplify the observation that PiB binding, similar to that seen in AD subjects, was seen in subsets of both NC and MCI subjects. MMSE = Mini-Mental State Examination; PiB-neg = PiB negative; PiB-pos = PiB positive; y/o = years old.
Fig. 2
Fig. 2
Scatter plot of global PiB DVR vs. FAQ in NC, MCI, and all subjects. There is a significant positive partial Spearman's rank correlation between global PiB retention and FAQ (higher scores indicate greater IADL impairment) in all subjects (prs = 0.45, p = 0.001) and in MCI subjects only (prs = 0.50, p = 0.002), but not in NC subjects only (prs = 0.04, p = 0.89).
Fig. 3
Fig. 3
Partial regression plot of adjusted global PiB DVR versus adjusted FAQ in all subjects. Global PiB DVR and FAQ have been adjusted for all other predictors in the model, including age, AMNART IQ, MMSE, and RAVLT delayed recall.
Fig. 4
Fig. 4
Partial regression plot of adjusted global PiB DVR versus adjusted FAQ in MCI subjects only. Global PiB DVR and FAQ have been adjusted for all other predictors in the model, including age and AMNART IQ.
See this image and copyright information in PMC

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