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. 2011 Oct 4;6(10):1789-91.
doi: 10.1002/cmdc.201100320. Epub 2011 Jul 20.

PET imaging of CXCR4 receptors in cancer by a new optimized ligand

Oliver Demmer  1 , Eleni Gourni, Udo Schumacher, Horst Kessler, Hans-Jürgen Wester
Affiliations
Free PMC article

PET imaging of CXCR4 receptors in cancer by a new optimized ligand

Oliver Demmer et al. ChemMedChem. .
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
CXCR4 ligands modified to introduce radioisotopes.
Figure 2
Figure 2
Structures of the best DOTA peptides for imaging. The DOTA moiety is depicted simplified and not representing the actual state of metal ion coordination.
Figure 3
Figure 3
a) PET summation images (90–110 min p.i.) of OH1 h-SCLC tumor-bearing nude mice using [68Ga]2 c (tracer-only study, injected dose: 230 μCi); b) Competition by co-injection of 50 μg cyclo-(d-Tyr 1-Arg 2-Arg 3-Nal 4-Gly 5) per mouse (injected dose: 300 μCi). The radioactivity scales have been normalized according the injected activity of each mouse.
See this image and copyright information in PMC

References

    1. van't Veer LJ, Bernards R. Nature. 2008;452:564. - PubMed
    1. Langer A. BMC Health Serv. Res. 2010;10:283. - PMC - PubMed
    1. Jiang Y, Wang M. Biomarkers Med. 2010;4:523. - PubMed
    1. Diamandis M, White NM, Yousef GM. Mol. Cancer Res. 2010;8:1175. - PubMed
    1. Pysz MA, Gambhir SS, Willmann JK. Clin. Radiol. 2010;65:500. - PMC - PubMed

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