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. 2011 Aug 17;133(32):12433-5.
doi: 10.1021/ja205339p. Epub 2011 Jul 27.

Total synthesis of landomycin A, a potent antitumor angucycline antibiotic

Xiaoyu Yang  1 , Boqiao Fu, Biao Yu
Affiliations

Total synthesis of landomycin A, a potent antitumor angucycline antibiotic

Xiaoyu Yang et al. J Am Chem Soc. .

Abstract

The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps.

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