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. 2011 Aug 12;411(4):768-73.
doi: 10.1016/j.bbrc.2011.07.022. Epub 2011 Jul 18.

Palladin is a novel binding partner of ILKAP in eukaryotic cells

Wang Zhou  1 , Shusen Cui, Shuhai Han, Baiqi Cheng, Yu Zheng, Yingjiu Zhang
Affiliations

Palladin is a novel binding partner of ILKAP in eukaryotic cells

Wang Zhou et al. Biochem Biophys Res Commun. .

Abstract

Palladin was a novel binding partner of ILKAP in eukaryotic cells. Palladin's C-terminal fragment including only its last three Ig domains (residues 710-1106) and the PP2C domain of ILKAP (residues 108-392) were necessary and sufficient for their interaction. The biological significance of the interaction between palladin and ILKAP was that palladin recruited the cytoplasmic ILKAP to initiate ILKAP-induced apoptosis. Our results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis.

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