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Review
. 2011 Oct 15;317(17):2391-6.
doi: 10.1016/j.yexcr.2011.07.006. Epub 2011 Jul 20.

Role of aquaporins in cell migration and edema formation in human brain tumors

Beatrice Nico  1 , Domenico Ribatti
Affiliations
Review

Role of aquaporins in cell migration and edema formation in human brain tumors

Beatrice Nico et al. Exp Cell Res. .

Abstract

The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration, angiogenesis, and tumor growth. This review article summarizes literature data concerning the involvement of AQP-1 and -4 in human brain tumor growth and edema formation and suggests a potential therapeutic approach by antagonizing their biological activity.

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