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Review
. 2011 May;31(3):300-9.
doi: 10.1016/j.semnephrol.2011.05.009.

Contrast-induced acute kidney injury: short- and long-term implications

Steven D Weisbord  1 , Paul M Palevsky
Affiliations
Review

Contrast-induced acute kidney injury: short- and long-term implications

Steven D Weisbord et al. Semin Nephrol. 2011 May.

Abstract

The intravascular administration of iodine-based contrast media remains a common cause of acute kidney injury and a leading cause of iatrogenic renal disease. Past research has elucidated the principal risk factors for contrast-induced acute kidney injury (CIAKI) and helped to establish the efficacy of various interventions for the prevention of this condition. The importance of preventing CIAKI has been underscored by a growing number of studies showing strong associations of CIAKI with serious adverse short- and long-term outcomes. However, it remains unclear whether these associations are causal. This is important because considerable health care resources are used to prevent CIAKI. If CIAKI is a marker, but not a mediator, of serious adverse downstream outcomes, more judicious and selective use of preventive care may be appropriate. Moreover, with an increasing number of studies reporting the underuse of coronary angiography in patients with acute coronary syndrome and underlying chronic kidney disease, presumably in part because of a fear of CIAKI, a clear understanding of whether this condition directly results in adverse downstream outcomes is essential. Careful inspection of past studies that investigated the association of CIAKI with adverse short- and long-term events sheds light on their strengths and weaknesses and provides insight into how future research may be better able to characterize the short- and long-term implications of this iatrogenic condition.

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Figures

Figure 1
Figure 1
Pathophysiology of contrast-induced acute kidney injury
Figure 2
Figure 2
Kidney function following coronary angiography among patients with post–angiography eGFR < 90 ml/min/1.73m2, according to acute kidney injury status* *Reprinted by permission from Macmillan Publishers Ltd: Kidney International ; James MT et al. Acute kidney injury following coronary angiography is associated with a long–term decline in kidney function.78;803–809,2010
Figure 3
Figure 3
Potential pathways to adverse patient-centered outcomes following contrast-enhanced imaging procedures
See this image and copyright information in PMC

References

    1. Barrett BJ. Contrast nephrotoxicity. J Am Soc Nephrol. 1994;5:125–37. - PubMed
    1. Parfrey PS, Griffiths SM, Barrett BJ, et al. Contrast material–induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study. N Engl J Med. 1989;320:143–9. - PubMed
    1. Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Contrast media-associated nephrotoxicity. Curr Opin Nephrol Hypertens. 1996;5:127–33. - PubMed
    1. Reddan D, Laville M, Garovic VD. Contrast-induced nephropathy and its prevention: What do we really know from evidence-based findings? J Nephrol. 2009;22:333–51. - PubMed
    1. McCullough PA. Contrast-induced acute kidney injury. J Am Coll Cardiol. 2008;51:1419–28. - PubMed

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