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. 2011 Nov;13(6):867-71.
doi: 10.1038/aja.2011.48. Epub 2011 Jul 25.

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

Mazen A Ghanem  1 , Manal A Safan, Ashraf A Ghanem, Gert R Dohle
Affiliations

The role of varicocele sclerotherapy in men with severe oligo-astheno-teratozoospermia

Mazen A Ghanem et al. Asian J Androl. 2011 Nov.

Abstract

The aim of this study was to verify the role of antegrade scrotal sclerotherapy for the treatment of varicoceles in infertile men with severe oligo-astheno-teratozoospermia (OAT). The 59 patients with severe OAT in this study underwent antegrade scrotal sclerotherapy for the treatment of varicoceles. The outcome was assessed in terms of improvement in semen parameters and spontaneous conception rate. Semen parameters and reproductive hormones were evaluated before antegrade sclerotherapy (AS) and 6 months after AS. After an average follow-up time of 34.8±3.2 months, significant improvement was noted in the mean sperm concentration, motility and morphology in 36 patients (61%). Spontaneous pregnancy occurred in nine couples (15%). Six months after treatment, inhibin B levels were significantly higher (P<0.04), whereas follicle-stimulating hormone (FSH) levels were significantly lower (P<0.001) than before treatment. Antegrade internal spermatic vein sclerotherapy can significantly improve seminal parameters and hormonal parameters in men with severe OAT and may even result in spontaneous pregnancy in couples who would otherwise be candidates for intracytoplasmic sperm injection (ICSI).

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References

    1. World Health Organization The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. Fertil Steril. 1992;57:1289–93. - PubMed
    1. Hadziselimovic F, Herzog B, Liebundgut B, Jenny P, Buser M. Testicular and vascular changes in children and adults with varicocele. J Urol. 1989;142:583–5. - PubMed
    1. Sayfan J, Siplovich L, Koltun L, Benyamin N. Varicocele treatment in pubertal boys prevents testicular growth arrest. J Urol. 1997;157:1456–7. - PubMed
    1. Paduch A, Niedzieliski J. Repair versus observation in adolescent varicocele: a prospective study. J Urol. 1997;158:1128–32. - PubMed
    1. Lund L, Tang YC, Roebuck D, Lee KH, Liu K, et al. Testicular catch-up growth after varicocele correction in adolescent. Pediatr Surg Int. 1999;15:234–7. - PubMed

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