Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:783528.
doi: 10.1155/2011/783528. Epub 2011 Jul 6.

Clinical therapeutics in pregnancy

Maisa N Feghali  1 , Donald R Mattison
Affiliations

Clinical therapeutics in pregnancy

Maisa N Feghali et al. J Biomed Biotechnol. 2011.

Abstract

Most drugs are not tested for use during pregnancy, consequently, labeling, which may include information about fetal safety, includes nothing about dosing, efficacy, or maternal safety. Yet these are concerns of health care providers considering treatment of disease during pregnancy. Therefore, the practitioner treats the pregnant woman with the same dose recommended for use in adults (typically men) or may decide not to treat the disease at all. However, is the choice of not treating a woman during pregnancy better than dealing with the challenges which accompany treatment? This paper, which summarizes metabolic and physiologic changes induced by pregnancy, illustrates that standard adult dosing is likely to be incorrect during pregnancy.

PubMed Disclaimer

References

    1. Black RA, Hill DA. Over-the-counter medications in pregnancy. American Family Physician. 2003;67(12):2517–2524. - PubMed
    1. Riley EH, Fuentes-Afflick E, Jackson RA, et al. Correlates of prescription drug use during pregnancy. Journal of Women’s Health. 2005;14(5):401–409. - PubMed
    1. Bonati M, Bortolus R, Marchetti F, Romero M, Tognoni G. Drug use in pregnancy: an overview of epidemiological (drug utilization) studies. European Journal of Clinical Pharmacology. 1990;38(4):325–328. - PubMed
    1. Rayburn WF, Farmer KC. Off-label prescribing during pregnancy. Obstetrics and Gynecology Clinics of North America. 1997;24(3):471–478. - PubMed
    1. Rayburn WF. A physician’s prerogative to prescribe drugs for off-label uses during pregnancy. Obstetrics and Gynecology. 1993;81(6):1052–1055. - PubMed

LinkOut - more resources