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. 2011 Sep 7;47(33):9321-3.
doi: 10.1039/c1cc13213j. Epub 2011 Jul 25.

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Mihai Ciobanu  1 , Kuo-Ting Huang, Jean-Pierre Daguer, Sofia Barluenga, Olivier Chaloin, Evelyne Schaeffer, Christopher G Mueller, Daniel A Mitchell, Nicolas Winssinger
Affiliations

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Mihai Ciobanu et al. Chem Commun (Camb). .

Abstract

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37,485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.

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