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Review
. 2011 Aug;30(4):197-206.
doi: 10.3109/08830185.2011.598978.

Important lessons derived from animal models of celiac disease

E V Marietta  1 , C S David, J A Murray
Affiliations
Review

Important lessons derived from animal models of celiac disease

E V Marietta et al. Int Rev Immunol. 2011 Aug.

Abstract

Several animal models have been recently developed to recapitulate various components of the complex process that is celiac disease. In addition to the increasing diversity of murine models there are now monkey models of celiac disease. Mouse strains and protocols have been developed that are now just beginning to address the complex interactions among the innate and adaptive immune responses to gluten, as well as gluten-dependent autoimmunity in celiac disease. The most important conclusion that these models have provided us with so far is that while all three components (innate gluten sensitivity, adaptive gluten sensitivity, and autoimmunity) are independent phenomena, all are necessary for celiac disease to develop.

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Conflict of interest statement

Declaration of Interest

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
The three aberrant responses to gluten necessary for celiac disease.
See this image and copyright information in PMC

References

    1. Hourigan CS. The molecular basis of coeliac disease. Clin Exp Med. 2006;6(2):53–9. - PubMed
    1. Batt RM, McLean L, Carter MW. Sequential morphologic and biochemical studies of naturally occurring wheat-sensitive enteropathy in Irish setter dogs. Dig Dis Sci. 1987;32(2):184–94. - PubMed
    1. Batt RM, Carter MW, McLean L. Wheat-sensitive enteropathy in Irish setter dogs: possible age-related brush border abnormalities. Res Vet Sci. 1985;39(1):80–3. - PubMed
    1. Hall EJ, Batt RM. Delayed introduction of dietary cereal may modulate the development of gluten-sensitive enteropathy in Irish setter dogs. J Nutr. 1991;121(11 Suppl):S152–3. - PubMed
    1. Hall EJ, Batt RM. Abnormal intestinal permeability could play a role in the development of gluten-sensitive enteropathy in Irish setter dogs. J Nutr. 1991;121(11 Suppl):S150–1. - PubMed

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