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Review
. 2011 Sep 13;108 Suppl 3(Suppl 3):15624-30.
doi: 10.1073/pnas.1103557108. Epub 2011 Jul 25.

Architecture, constraints, and behavior

John C Doyle  1 , Marie Csete
Affiliations
Review

Architecture, constraints, and behavior

John C Doyle et al. Proc Natl Acad Sci U S A. .

Abstract

This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational features are hidden during normal function of a system but are fundamental for understanding the nature, design, and function of complex biologic and technologic systems.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Marder E. Variability, compensation and modulation in neurons and circuits. Proc Natl Acad Sci USA. 2011;108(Suppl. 3):15542–15548. - PMC - PubMed
    1. Purves D, Wojtach WT, Lotto RB. Understanding vision in wholly empirical terms. Proc Natl Acad Sci USA. 2011;108(Suppl. 3):15588–15595. - PMC - PubMed
    1. Chabris C, Simons D. The Invisible Gorilla: And Other Ways Our Intuitions Deceive Us. New York: Crown Publishing Group; 2010.
    1. Gazzaniga M. Who Is in Charge: Free Will and the Science of the Brain. New York: Harper Collins; 2011.
    1. Linden DJ. The Compass of Pleasure: How Our Brains Make Fatty Foods, Orgasm, Exercise, Marijuana, Generosity, Vodka, Learning, and Gambling Feel So Good. New York: Viking Press; 2011.

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