Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;2(4):171-81.
doi: 10.1177/1756287210375270.

Hormone therapy in the management of prostate cancer: evidence-based approaches

Affiliations

Hormone therapy in the management of prostate cancer: evidence-based approaches

Leonard G Gomella et al. Ther Adv Urol. 2010 Aug.

Abstract

Hormonal therapy has been the standard for advanced prostate cancer for over 60 years. Recently, the utility of androgen ablation through various means has been demonstrated for earlier stages of disease. In particular, the strongest evidence to date involves the use of hormonal therapy in combination with radiation therapy. In this article we review the basic concepts in hormonal ablation for prostate cancer and review the evidence-based studies that support the use of hormonal therapy in early stage prostate cancer.

Keywords: androgen deprivation therapy; combined androgen blockade; hormonal therapy; prostate cancer.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Abrahamsson P.A. (2010) Potential benefits of intermittent androgen suppression therapy in the treatment of prostate cancer: a systematic review of the literature. Eur Urol 57: 49–59 - PubMed
    1. Akaza H., Hinotsu S., Usami M., Arai Y., Kanetake H., Naito S., et al. (2009) Combined androgen blockade with bicalutamide for advanced prostate cancer: long-term follow-up of a phase 3, double-blind, randomized study for survival. Cancer 115: 3437–3445 - PubMed
    1. Arai Y., Akaza H., Deguchi T., Fujisawa M., Hayashi M., Hirao Y., et al. (2008) Evaluation of quality of life in patients with previously untreated advanced prostate cancer receiving maximum androgen blockade therapy or LHRHa monotherapy: a multicenter, randomized, doubleblind, comparative study. J Cancer Res Clin Oncol 134: 1385–1396 - PubMed
    1. Aus G., Abrahamsson P.A., Ahlgren G., Hugosson J., Lundberg S., Schain M., et al. (2002) Three-month neoadjuvant hormonal therapy before radical prostatectomy: a 7-year follow-up of a randomized controlled trial. BJU Int 90: 561–566 - PubMed
    1. Bolla M., Collette L., Blank L., Warde P., Dubois J.B., Mirimanoff R.O., et al. (2002) Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomized trial. Lancet 360: 103–106 - PubMed

LinkOut - more resources