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Review
. 2011 Jul;7(4):411-7.
doi: 10.1586/eci.11.27.

Mepolizumab in eosinophilic disorders

J Pablo Abonia  1 , Philip E Putnam
Affiliations
Review

Mepolizumab in eosinophilic disorders

J Pablo Abonia et al. Expert Rev Clin Immunol. 2011 Jul.

Abstract

Mepolizumab (Bosatria(®), GlaxoSmithKline) is a biologic agent developed to treat asthma. It represents a humanized monoclonal antibody of IgG1 κ type, which targets human IL-5 and thus prevents its interaction with the α-chain of the IL-5 receptor. To date, it has not been approved for use in any eosinophil-related disorder; however, several studies have suggested some therapeutic benefit across a spectrum of eosinophil-related disorders. This article evaluates the currently available preclinical and clinical studies, and the impact of mepolizumab against a variety of eosinophilic disorders.

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Conflict of interest statement

Financial & competing interests disclosure

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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