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. 2011 Jul 26:2011:0314.

Gastroenteritis in children

Jacqueline R Dalby-Payne  1 , Elizabeth J Elliott
Affiliations

Gastroenteritis in children

Jacqueline R Dalby-Payne et al. BMJ Clin Evid. .

Abstract

Introduction: Acute gastroenteritis results from infection of the gastrointestinal tract, most commonly with a virus. It is characterised by rapid onset of diarrhoea with or without vomiting, nausea, fever, and abdominal pain. Diarrhoea is defined as the frequent passage of unformed, liquid stools. Regardless of the cause, the mainstay of management of acute gastroenteritis is provision of adequate fluids to prevent and treat dehydration.

Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent acute gastroenteritis in children? What are the effects of treatments for acute gastroenteritis in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

Results: We found 42 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Conclusions: In this systematic review, we present information relating to the effectiveness and safety of: rotavirus vaccines for the prevention of gastroenteritis; enteral rehydration solutions (oral or gastric), lactose-free feeds, loperamide, probiotics, and zinc for the treatment of gastroenteritis; and ondansetron for the treatment of vomiting.

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References

    1. Armon K, Elliott EJ. Acute gastroenteritis. In: Moyer VA, Elliott EJ, Davis RL, eds. Evidence based pediatrics and child health, 2nd ed. London, UK: BMJ Books, 2004:377–392.
    1. American Academy of Pediatrics (APP). Practice parameter: the management of acute gastroenteritis in young children. American Academy of Pediatrics, Provisional Committee on Quality Improvement, Subcommittee on Acute Gastroenteritis. Pediatrics 1996;97:424–435. - PubMed
    1. Critchley M. Butterworths medical dictionary, 2nd ed. London, UK: Butterworths, 1986.
    1. UNICEF, World Health Organization. Diarrhoea: why children are still dying and what can be done. 2009. Available at http://whqlibdoc.who.int/publications/2009/9789241598415_eng.pdf (last accessed 13 February 2014).
    1. World Health Organization. Children's environmental health. Available at http://www.who.int/ceh/en/ (last accessed 31 March 2014).

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