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. 2011 Oct 1;58(2):188-92.
doi: 10.1097/QAI.0b013e31822d0433.

The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers

Woottichai Khamduang  1 , Gonzague Jourdain, Wasna Sirirungsi, Prapaisri Layangool, Suparat Kanjanavanit, Pornsuda Krittigamas, Karin Pagdi, Rosalin Somsamai, Surat Sirinontakan, Temsiri Hinjiranandana, Wanna Ardonk, Suchat Hongsiriwon, Sirisak Nanta, Thitiporn Borkird, Marc Lallemant, Kenneth McIntosh, Nicole Ngo-Giang-Huong; Program for HIV Prevention and Treatment (PHPT) Study Group
Collaborators, Affiliations

The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers

Woottichai Khamduang et al. J Acquir Immune Defic Syndr. .

Abstract

Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.

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Conflict of interest statement

Conflict of Interest Declaration: None of the authors has any commercial or other association that might pose a conflict of interest.

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