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. 2012 Jun;36(6):783-9.
doi: 10.1038/ijo.2011.152. Epub 2011 Jul 26.

Association of adipose tissue blood flow with fat depot sizes and adipokines in women

J Andersson  1 , F Karpe, L-G Sjöström, K Riklund, S Söderberg, T Olsson
Affiliations

Association of adipose tissue blood flow with fat depot sizes and adipokines in women

J Andersson et al. Int J Obes (Lond). 2012 Jun.

Abstract

Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.

Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.

Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.

Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.

Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow.

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