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Comparative Study
. 2011 Sep;28(10):911-5.
doi: 10.1007/s10815-011-9614-9. Epub 2011 Jul 27.

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Martha Luna  1 , Catherine Bigelow, Marlena Duke, Jane Ruman, Benjamin Sandler, Lawrence Grunfeld, Alan B Copperman
Affiliations
Comparative Study

Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?

Martha Luna et al. J Assist Reprod Genet. 2011 Sep.

Abstract

Purpose: To determine if patients with a low response to controlled ovarian hyperstimulation during IVF benefit from intracytoplasmic sperm injection (ICSI) METHODS: Retrospective analysis of 350 IVF cycles in which four or fewer oocytes were retrieved. Severe male factor cases were excluded from analysis. Conventional insemination (CI) and ICSI were compared, with primary outcome measures of fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, and pregnancy loss rate.

Result(s): Fertilization rates per oocyte retrieved for CI and ICSI were comparable (51.5% vs. 51.8%). Parallel implantation rates (22% vs. 25%), clinical pregnancy rates (32.8% vs. 33.3%), and loss rates (26.7% vs. 39.5%) were also noted. No difference in cancelled cycles was reported.

Conclusion(s): Our results demonstrate that in the presence of normal semen parameters, low egg number is not an indication to perform ICSI.

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