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. 2011;38(2):162-4.

Is there any effect of fetal gender on the markers of first trimester Down's syndrome screening?

G O Ajayi  1
Affiliations
  • PMID: 21793280

Is there any effect of fetal gender on the markers of first trimester Down's syndrome screening?

G O Ajayi. Clin Exp Obstet Gynecol. 2011.

Abstract

Introduction: At present, the most effective trisomy 21-screening method is the estimate of risk combining maternal age, fetal nuchal translucency, beta-hCG and pregnancy-associated PAPP-A.

Objective: The aim of this study was to investigate the possible effect of fetal gender in first trimester Down's syndrome screening markers.

Design: Retrospective study.

Setting: Prenatal Diagnosis Centre in a tertiary hospital in Lagos.

Methods: Of a total of 350 pregnancies in which fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A were performed were included in this study. These markers were investigated to see if they differed on the basis of fetal gender.

Results: PAPP-A levels were higher in female fetuses although the difference was not statistically significant. Nuchal translucency was 0.099 mm more in male fetuses.

Conclusion: The results suggest that first trimester markers differ on gender but are of no clinical significance, confirming the result of other authors.

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