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Review
. 2011 Jul 28;365(4):347-57.
doi: 10.1056/NEJMra1003071.

Microbial genomics and infectious diseases

David A Relman  1
Affiliations
Review

Microbial genomics and infectious diseases

David A Relman. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Genome Projects and Completed Genomes since 1995
Panel A shows a cumulative plot of the number of genome projects — involving microbial (bacterial and archaeal), eukaryotic, and viral genomes — and metagenome projects, according to the release year at the National Center for Biotechnology Information since 1995. Panel B shows the number of completed microbial genome sequences according to year. (The most recent data were collected on April 21, 2011.)
Figure 2
Figure 2. Unexpected Diversity of Virulence Factors for Staphylococcus aureus, as Shown by Comparative Genome Analysis
Shown are phage-related, virulence-associated genomic islands from different strains of S. aureus (listed to the left of the genomes), with their genes colored according to functional categories. The islands are located at specific phage integration sites in the S. aureus genome and are responsible for the production of toxins by these strains. The numbers at the top are distance markers along the genomic islands. Data are adapted from Novick et al.
Figure 3
Figure 3. Microbial Genomics and Tool Development
A genome sequence facilitates the development of a variety of tools and approaches for understanding, manipulating, and mitigating the overall effect of a microbe. The sequence provides insight into the population structure and evolutionary history of a microbe for epidemiologic investigation, information with which to develop new diagnostic tests and cultivation methods, new targets of drug development, and antigens for vaccine development.
See this image and copyright information in PMC

References

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