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. 2011 Oct 17;12(15):2267-9.
doi: 10.1002/cbic.201100431. Epub 2011 Jul 27.

A "diels-alderase" at last

Craig A Townsend  1
Affiliations

A "diels-alderase" at last

Craig A Townsend. Chembiochem. .

Abstract

Diels this Alder your thinking? Electrocyclization reactions are exceedingly rare in metabolic pathways. Why is this so? Recently a [4+2] cycloaddition catalyzed by a monofunctional "Diels-Alderase" has been characterized. How does a 500-fold rate enhancement shown by this enzyme stack up?

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