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Randomized Controlled Trial
. 2011 Nov;37(6):487-90.
doi: 10.3109/00952990.2011.598591. Epub 2011 Jul 29.

Bupropion-SR for smoking cessation in early recovery from alcohol dependence: a placebo-controlled, double-blind pilot study

Maher Karam-Hage  1 , Stephen Strobbe, Jason D Robinson, Kirk J Brower
Affiliations
Randomized Controlled Trial

Bupropion-SR for smoking cessation in early recovery from alcohol dependence: a placebo-controlled, double-blind pilot study

Maher Karam-Hage et al. Am J Drug Alcohol Abuse. 2011 Nov.

Abstract

We conducted a double-blind pilot study involving 11 alcohol- and nicotine-dependent patients randomized to receive either bupropion or placebo. Four of six patients on bupropion and one of five patients on placebo were abstinent from smoking at the end of medication phase. Those in the bupropion group reported significantly less craving (p < .02) and less exposure to cigarette smoke over time (expired carbon monoxide; p < .01). There were no serious adverse events and no main effects of medication group on either per subject or total number of adverse events. All those who completed treatment remained abstinent from alcohol.

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Figures

Figure 1
Figure 1
a. Results for continuous measures of smoking confirmed by expired CO b. Results of cigarette craving measures by progression of time in weeks
See this image and copyright information in PMC

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