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. 2011 Aug 12;333(6044):850-6.
doi: 10.1126/science.1205669. Epub 2011 Jul 28.

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

Davide Corti  1 , Jarrod Voss, Steven J Gamblin, Giosiana Codoni, Annalisa Macagno, David Jarrossay, Sebastien G Vachieri, Debora Pinna, Andrea Minola, Fabrizia Vanzetta, Chiara Silacci, Blanca M Fernandez-Rodriguez, Gloria Agatic, Siro Bianchi, Isabella Giacchetto-Sasselli, Lesley Calder, Federica Sallusto, Patrick Collins, Lesley F Haire, Nigel Temperton, Johannes P M Langedijk, John J Skehel, Antonio Lanzavecchia
Affiliations

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

Davide Corti et al. Science. .

Abstract

The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. Passive transfer of this antibody conferred protection to mice and ferrets. Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain. This antibody may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.

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Comment in

  • Biochemistry. Catching a moving target.
    Wang TT, Palese P. Wang TT, et al. Science. 2011 Aug 12;333(6044):834-5. doi: 10.1126/science.1210724. Science. 2011. PMID: 21836007 No abstract available.
  • New clues for flu vaccine design.
    Crunkhorn S. Crunkhorn S. Nat Rev Drug Discov. 2011 Sep 30;10(10):733. doi: 10.1038/nrd3567. Nat Rev Drug Discov. 2011. PMID: 21959284 No abstract available.

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