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. 2011 Oct;42(10):2940-3.
doi: 10.1161/STROKEAHA.110.608075. Epub 2011 Jul 28.

Association between Mycoplasma pneumonia and increased risk of ischemic stroke: a nationwide study

Chia-Hung Chiang  1 , Chin-Chou Huang, Wan-Leong Chan, Yu-Chun Chen, Tzeng-Ji Chen, Shing-Jong Lin, Jaw-Wen Chen, Hsin-Bang Leu
Affiliations

Association between Mycoplasma pneumonia and increased risk of ischemic stroke: a nationwide study

Chia-Hung Chiang et al. Stroke. 2011 Oct.

Abstract

Background and purpose: Infections have been hypothesized to play a role in vascular disease. The association between Mycoplasma pneumoniae (MP) infection and ischemic stroke remained undetermined.

Methods: A total of 1094 patients with MP infection were enrolled as the study group and compared with 5168 sex-, age-, and comorbidity-matched subjects without MP, to be followed up prospectively from January 2003 to December 2007 for development of ischemic stroke.

Results: During a maximum 5-year follow-up period, 49 patients with ischemic stroke were identified. Subjects with MP infection were significantly associated with increased risk of ischemic stroke compared with controls (1.10% versus 0.72%, respectively; P=0.01). The logrank test showed that patients with MP had significantly higher incidence of stroke development than did those without MP (P=0.046). After Cox model adjustment for risk factors and comorbidities, MP infection was still independently associated with increased risk of stroke (hazard ratio [HR], 2.07; 95% CI, 1.05-4.03).

Conclusions: We conclude that MP infection is independently associated with risk of subsequent ischemic stroke development.

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