Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 May;31(5):671-82.
doi: 10.1007/s10096-011-1357-0. Epub 2011 Jul 29.

Initial microbial spectrum in severe secondary peritonitis and relevance for treatment

O van Ruler  1 , J J S Kiewiet, R J van Ketel, M A Boermeester; Dutch Peritonitis Study Group
Collaborators, Affiliations
Randomized Controlled Trial

Initial microbial spectrum in severe secondary peritonitis and relevance for treatment

O van Ruler et al. Eur J Clin Microbiol Infect Dis. 2012 May.

Abstract

This study aims to determine whether abdominal microbial profiles in early severe secondary peritonitis are associated with ongoing infection or death. The study is performed within a randomized study comparing two surgical treatment strategies in patients with severe secondary peritonitis (n = 229). The microbial profiles of cultures retrieved from initial emergency laparotomy were tested with logistic regression analysis for association with 'ongoing infection needing relaparotomy' and in-hospital death. No microbial profile or the presence of yeast or Pseudomonas spp. was related to the risk of ongoing infection needing relaparotomy. Resistance to empiric therapy for gram positive cocci and coliforms was moderately associated with ongoing abdominal infection (OR 3.43 95%CI 0.95-12.38 and OR 7.61, 95%CI 0.75-76.94). Presence of only gram positive cocci, predominantly Enterococcus spp, was borderline independently associated with in-hospital death (OR 3.69, 95%CI 0.99-13.80). In secondary peritonitis microbial profiles do not predict ongoing abdominal infection after initial emergency laparotomy. However, the moderate association of ongoing infection with resistance to the empiric therapy compels to more attention for resistance when selecting empiric antibiotic coverage.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart of patient inclusion and overall culture results per microbial profile
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Outcome of community- versus hospital-acquired intra-abdominal infections in intensive care unit: a retrospective study.
    Abaziou T, Vardon-Bounes F, Conil JM, Rouget A, Ruiz S, Grare M, Fourcade O, Suc B, Leone M, Minville V, Georges B. Abaziou T, et al. BMC Anesthesiol. 2020 Dec 1;20(1):295. doi: 10.1186/s12871-020-01209-1. BMC Anesthesiol. 2020. PMID: 33261586 Free PMC article.
  • Antibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis.
    Grotelüschen R, Heidelmann LM, Lütgehetmann M, Melling N, Reeh M, Ghadban T, Dupree A, Izbicki JR, Bachmann KA. Grotelüschen R, et al. Sci Rep. 2020 Oct 29;10(1):18588. doi: 10.1038/s41598-020-73356-x. Sci Rep. 2020. PMID: 33122689 Free PMC article. Clinical Trial.
  • [Surgical treatment of secondary peritonitis: A continuing problem. German version].
    van Ruler O, Boermeester MA. van Ruler O, et al. Chirurg. 2016 Jan;87(1):13-9. doi: 10.1007/s00104-015-0115-8. Chirurg. 2016. PMID: 26689581 Review. German.
  • Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference.
    Sartelli M, Catena F, Abu-Zidan FM, Ansaloni L, Biffl WL, Boermeester MA, Ceresoli M, Chiara O, Coccolini F, De Waele JJ, Di Saverio S, Eckmann C, Fraga GP, Giannella M, Girardis M, Griffiths EA, Kashuk J, Kirkpatrick AW, Khokha V, Kluger Y, Labricciosa FM, Leppaniemi A, Maier RV, May AK, Malangoni M, Martin-Loeches I, Mazuski J, Montravers P, Peitzman A, Pereira BM, Reis T, Sakakushev B, Sganga G, Soreide K, Sugrue M, Ulrych J, Vincent JL, Viale P, Moore EE. Sartelli M, et al. World J Emerg Surg. 2017 May 4;12:22. doi: 10.1186/s13017-017-0132-7. eCollection 2017. World J Emerg Surg. 2017. PMID: 28484510 Free PMC article. Review.
  • Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).
    Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike… See abstract for full author list ➔ Sartelli M, et al. World J Emerg Surg. 2016 Jul 15;11:33. doi: 10.1186/s13017-016-0089-y. eCollection 2016. World J Emerg Surg. 2016. PMID: 27429642 Free PMC article. Review.
See all "Cited by" articles

References

    1. Lamme B, Mahler CW, van Till JW, van Ruler O, Gouma DJ, Boermeester MA. Relaparotomy in secondary peritonitis. Planned relaparotomy or relaparotomy on demand? Chirurg. 2005;76:856–867. doi: 10.1007/s00104-005-1086-y. - DOI - PubMed
    1. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32:858–873. doi: 10.1097/01.CCM.0000117317.18092.E4. - DOI - PubMed
    1. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118:146–155. doi: 10.1378/chest.118.1.146. - DOI - PubMed
    1. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115:462–474. doi: 10.1378/chest.115.2.462. - DOI - PubMed
    1. Anaya DA, Nathens AB. Risk factors for severe sepsis in secondary peritonitis. Surg Infect (Larchmt) 2003;4:355–362. doi: 10.1089/109629603322761418. - DOI - PubMed

Publication types

Substances