Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Aug;4(4):407-9.
doi: 10.1586/ehm.11.40.

The safety and efficacy of hydroxycarbamide in infants with sickle cell anemia

Clare Wykes  1 , David C Rees
Affiliations
Comment

The safety and efficacy of hydroxycarbamide in infants with sickle cell anemia

Clare Wykes et al. Expert Rev Hematol. 2011 Aug.

Abstract

The BABYHUG study is the first randomized controlled prospective trial of hydroxycarbamide in infants with sickle cell anemia to look at its effect on organ function. Almost 200 patients were recruited, irrespective of disease severity, over a 3-year period and followed for 2 years. The primary end points of splenic function and glomerular filtration rate were not reached. The trial did show a benefit in frequency of pain, dactylitis, acute chest syndrome, hospital admissions and transfusion requirements. Adverse effects were low.

PubMed Disclaimer

Comment on

LinkOut - more resources