doi: 10.1111/j.1528-1167.2011.03200.x.
Epub 2011 Jul 29.
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm
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- PMID: 21801169
- DOI: 10.1111/j.1528-1167.2011.03200.x
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Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm
Epilepsia.
2011 Sep.
Abstract
Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm.
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
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