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. 2011 Aug;17(8):1484-7.
doi: 10.3201/eid1708.110165.

Human parvovirus 4 as potential cause of encephalitis in children, India

Laura A Benjamin  1 , Penny Lewthwaite, Ravi Vasanthapuram, Guoyan Zhao, Colin Sharp, Peter Simmonds, David Wang, Tom Solomon
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Human parvovirus 4 as potential cause of encephalitis in children, India

Laura A Benjamin et al. Emerg Infect Dis. 2011 Aug.

Abstract

To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.

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Figures

Figure
Figure
Phylogenetic analysis of (A) complete nonstructural (NS) and (B) viral protein (VP) 1/VP 2 gene sequences of human parvovirus 4 (PARV4) variants isolated from patients with encephalitis of unknown etiology using 167 available sequences from human PARV4 variants (genotypes 1–3). Blue, study sample; red, genotype 1; orange, genotype 2; yellow, genotype 3. The porcine hokovirus sequence (GenBank accession no. EU200671) was used as an outgroup (not shown). The trees were constructed by neighbor-joining of pairwise maximum-composite likelihood corrected distances between nucleotide sequences; bootstrap values ≈70% are shown. Scale bars represent an evolutionary distance of 0.05.
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