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. 2011 Aug;17(8):1544-8.
doi: 10.3201/eid1708.101556.

Aichi virus shedding in high concentrations in patients with acute diarrhea

Jan Felix Drexler  1 , Sigrid Baumgarte, Luciano Kleber de Souza Luna, Monika Eschbach-Bludau, Alexander N Lukashev, Christian Drosten
Affiliations

Aichi virus shedding in high concentrations in patients with acute diarrhea

Jan Felix Drexler et al. Emerg Infect Dis. 2011 Aug.

Abstract

We assessed Aichi virus shedding in patients with gastroenteritis and negative test results for other viral and bacterial infections. High concentrations of up to 1.32 × 1012 RNA copies/g stool were found in 10 (2.0%) of 499 outpatients sampled in northern Germany, 2004. These data substantiate Aichi virus pathogenicity in humans.

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Figures

Figure 1
Figure 1
Age distribution of cohorts tested in study of Aichi virus in patients with acute diarrhea, Germany. A) Patients from food-associated diarrhea outbreaks (kindergartens, canteens, or retirement homes); B) outpatients seen for gastroenteritis by general practitioners; C) nongastroenteritis control patients for the outpatient study cohort. Arrows indicate patients who had positive test results for Aichi virus by real-time reverse transcription PCR.
Figure 2
Figure 2
Neighbor-joining phylogeny of Aichi virus (AiV) viral protein 1 gene of strains from study of AiV in patients with acute diarrhea (boldface), Germany, compared with strains from GenBank. The tree was generated by using MEGA4 (www.megasoftware.net) using the maximum-composite likelihood nucleotide substitution model and complete deletion option. Porcine kobuvirus was used as an outgroup (branch truncated as indicated by slashed lines). Bootstrap values from 1,000 reiterations are depicted next to root points. The final dataset corresponded to nucleotide positions 3,034–3,663 in AiV GenBank accession no. AB040749. Scale bar indicates number of base substitutions per site.
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