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Review
. 2011 Nov;96(1-4):10-3.
doi: 10.1016/j.prostaglandins.2011.07.001. Epub 2011 Jul 27.

Prostaglandin E2 modulation of blood pressure homeostasis: studies in rodent models

Christina E Swan  1 , Richard M Breyer
Affiliations
Review

Prostaglandin E2 modulation of blood pressure homeostasis: studies in rodent models

Christina E Swan et al. Prostaglandins Other Lipid Mediat. 2011 Nov.

Abstract

Hypertension is a well established risk factor for cardiovascular diseases such as stroke and is the leading cause of chronic kidney failure. Although a number of pharmacologic agents are available for the treatment of hypertension including agents that affect the renin-angiotensin-aldosterone system (RAAS), unmet needs in the treatment of hypertension suggest that identification of novel pharmacological targets would be an important healthcare goal. One potential target is prostaglandin E(2) (PGE(2)), a potent lipid mediator with a diverse and sometimes opposing range of biological effects. PGE(2) signals through four subtypes of G-protein coupled receptors designated EP1 through EP4. PGE(2) functions primarily as a vasodepressor; under certain conditions PGE(2) administration mediates vasopressor activity. This review focuses on the current understanding of the roles of PGE(2) receptors in vascular reactivity, hypertension and end-organ damage.

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Figures

Figure 1
Figure 1
The role of EP receptors as regulators of blood pressure. The vasodepressor EP2 and EP4 receptors are functionally antagonistic to the pressor EP1 and EP3 receptors.
See this image and copyright information in PMC

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