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Randomized Controlled Trial
. 2011 Aug;13(8):577-87.
doi: 10.1016/j.jfms.2011.05.012.

Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats

Philippe R Hennet  1 , Guy A L Camy, David M McGahie, Maxime V Albouy
Affiliations
Randomized Controlled Trial

Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats

Philippe R Hennet et al. J Feline Med Surg. 2011 Aug.

Abstract

Chronic caudal stomatitis with alveolar/buccal mucositis in calicivirus-positive cats is the most severe presentation of feline chronic gingivostomatitis. Refractory cases are helped by antibiotic and anti-inflammatory treatments often including glucocorticoids. In order to evaluate the comparative efficacy of oromucosal administration of recombinant feline interferon omega (rFeIFN-ω) versus oral administration of glucocorticoids, a randomised, multi-centre, controlled, double-blind study was performed in 39 cats. The progression of behavioural, clinical and lesional scores was assessed over 90 days. Daily oromucosal treatment with 0.1 MU of rFeIFN-ω was associated with a significant improvement of clinical lesions (caudal stomatitis and alveolar/buccal mucositis) and a decrease of pain scores from D0 to D90. Although no such statistical improvement was noticed in the prednisolone group, there was, however, no significant difference between the two groups for most of the parameters, except pain at D60 and D90.

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Conflict of interest statement

This study was sponsored by Virbac SAS, France.

Figures

Fig 1.
Fig 1.
Feline chronic gingivostomatitis.
Fig 2.
Fig 2.
Progression of the four behavioural scores. †Statistically significant intragroup difference from D0. ‡Statistically significant difference between groups.
Fig 3.
Fig 3.
Progression of pain on opening the mouth score. †Statistically significant intragroup difference from D0. ‡Statistically significant difference between group.
Fig 4.
Fig 4.
Progression of lesional scores.
See this image and copyright information in PMC

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